Analysis of an Adulterated Herbal Medicinal Product using UPLC-Qtof-MS
Mark Powell, Ph.D.
Monday, June 17, 2013
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Chapters
Analysis of an Adulterated Herbal Medicinal Product using UPLC-Qtof-MS
Introduction
The Project at Quay Pharma
Quay’s Approach
Quay HPLC-UV Chromatogram For the Herbal Product
The Challenge!
Follow up on Chlorpheniramine
Corydaline and Chlorpheniramine Have Different HPLC-UV Properties
Corydaline and Chlorpheniramine Have Different HPLC-UV Properties
Quay’s Initial Conclusion
More Unanswered Questions
Need analysis by LC-MS with data reduction software
UPLC/Qtof MS Study
UPLC/Qtof MS Results: Adulterants
Adulterants: Detected Amount vs. Therapeutic Dose
Do HPB Capsules Contain What’s Claimed?
Markers for Only 3 Out of the 13 Listed Herbs Found
Are the Capsules Contents Consistent?
LC-MS Chromatograms (BPI) of HPB Capsule Samples
PCA Score Plot of HPB Batches (ESI-)
PCA Loading Plot (ESI-)
Graph
All Key Chemical Markers are Present in Gancao
Markers for Only 3 Out of the 13 Listed Herbs Found
Gancao is the Major Herbal Ingredient
Answers to Initial Questions
Conclusions
Acknowledgements
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