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Analysis of an Adulterated Herbal Medicinal Product using UPLC-Qtof-MS

Mark Powell, Ph.D.
Monday, June 17, 2013
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Chapters

  • Analysis of an Adulterated Herbal Medicinal Product using UPLC-Qtof-MS
  • Introduction
  • The Project at Quay Pharma
  • Quay’s Approach
  • Quay HPLC-UV Chromatogram For the Herbal Product
  • The Challenge!
  • Follow up on Chlorpheniramine
  • Corydaline and Chlorpheniramine Have Different HPLC-UV Properties
  • Corydaline and Chlorpheniramine Have Different HPLC-UV Properties
  • Quay’s Initial Conclusion
  • More Unanswered Questions
  • Need analysis by LC-MS with data reduction software
  • UPLC/Qtof MS Study
  • UPLC/Qtof MS Results: Adulterants
  • Adulterants: Detected Amount vs. Therapeutic Dose
  • Do HPB Capsules Contain What’s Claimed?
  • Markers for Only 3 Out of the 13 Listed Herbs Found
  • Are the Capsules Contents Consistent?
  • LC-MS Chromatograms (BPI) of HPB Capsule Samples
  • PCA Score Plot of HPB Batches (ESI-)
  • PCA Loading Plot (ESI-)
  • Graph
  • All Key Chemical Markers are Present in Gancao
  • Markers for Only 3 Out of the 13 Listed Herbs Found
  • Gancao is the Major Herbal Ingredient
  • Answers to Initial Questions
  • Conclusions
  • Acknowledgements
 

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