Snapshot Proteomics: A Cellular Snapshot of Compound Treatment
Christian Loch MPH, PhD
Friday, June 30, 2017
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Chapters
Introduction
Snapshot Proteomics = core technology powering three applications
More information!
Why PTM?
Why Proteomics?
Same Genome!
Snapshot Proteomics workflow
About the arrays
Proteomic Activity Networks (ProActiN)
Reference intervals for 70 protein analytes in plasma
An impossibly wide dynamic range without enzymatic amplification
Small Molecule Accelerated Research Tool
Two test cases
Sorafenib: multi-kinase inhibitor
18,180 proteins examined, 3320 changes in phosphorylation
495 changes observed in ubiquitylation
Conclusions
Closing
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