Development of a High Throughput Acoustic Loading System for Mass Spectrometry
Dr. Jonathan Wingfield
Wednesday, March 2, 2016
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Chapters
Introduction
Pushing the boundaries of science in the UK
Advanced Research
Drive technology development to enable scientific excellence
Why use MS to screen?
The issue with MS as a screening technology
Innovation is the creation
What can we achieve with acoustics?
Generation 1
If at first you don’t succeed …….
Small Molecule Ionization
Generation 2 - Ionisation options
Switching Polarity
Ubiquitin protein spectra
Generation 3 unit – ToF MS
Rapid Sampling with Acoustic Source
Applications
Challenges of bioassays
Alternative Ionization Strategy
Some early DART data
DART fragmentation patterns can be very predictable
Summary
Acknowledgements
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