Development of a High Throughput Acoustic Loading System for Mass Spectrometry
Dr. Jonathan Wingfield
Wednesday, March 2, 2016
Pushing the boundaries of science in the UK
Drive technology development to enable scientific excellence
Why use MS to screen?
The issue with MS as a screening technology
Innovation is the creation
What can we achieve with acoustics?
If at first you don’t succeed …….
Small Molecule Ionization
Generation 2 - Ionisation options
Ubiquitin protein spectra
Generation 3 unit – ToF MS
Rapid Sampling with Acoustic Source
Challenges of bioassays
Alternative Ionization Strategy
Some early DART data
DART fragmentation patterns can be very predictable
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