ADHD and OCD genetics: Populations, endophenotypes and quantitative traits
Russell Schachar, MD, FRCP(C)
Monday, December 3, 2018
Funders & Conflicts of Interest
Attention-deficit Hyperactivity Disorder Obsessive Compulsive Disorder
Spit for Science
Partnering with Ontario Science Centre
Quantitative Psychiatric Traits
Overview of Sample
Reported Psychiatric Diagnoses
Toronto Obsessive-Compulsive Scale (TOCS)
Quantitative Psychiatric Traits are Heritable
Preparation of Genetic Samples & Genotyping
First Genome-Wide Loci for OCD Traits
Replication in European Pediatric Samples
Does the lower end of the distribution matter?
Hypothesis-Driven GWAS (GWAS-HD)
OCD Traits Associated with Brain Development Genes
OCD Traits are Associated only with Diagnosed OCD Genetic Risk
Copy Number Variants (CNVs)
CNV Burden Varies by Psychiatric Trait
Potential of Spit for Science Approach
Spit for Science II
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