From "omics" biomarker discovery to novel clinical tests: strategies and challenges
Dr. Peter Schulz-Knappe
Wednesday, September 9, 2015
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Chapters
Introduction
Autoimmune Diseases
Differential Diagnosis: The Opportunity
The Testing Population
Autoantibodies as clinical analytes
Introduction of New Clinical Biomarkers is Slowing
Outcome of high tech proteomics studies
Number of novel protein marker too low
Biomarker Development
Game Plan
The Technology - SeroTag®
SeroTag® Platform
Screening of serum samples
The SLE Challenge (Systemic Lupus)
Benchmarking
SLE Discovery Strategy
SLE Studies
SLE Robust Results
SLE Development: Panel Selection Process
SLE Development: Next Steps
SLE Study Summary
Protagen NavigAID SLE The SLE Stratification Array
Protagen NavigAID SLE Definitions
Differential diagnosis
Protagen NavigAID SLE: Patient stratification based on INF-inducible signature
Protagen NavigAID SLE: Patient Stratification into Subgroups
Protagen NavigAID SLE: The SLE Stratification Array
Conclusions
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