Watch Webinar: Diagnostic Applications of the RNAscope® RNA ISH Technology
Rob Monroe, MD, PhD
Wednesday, March 28, 2018
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Chapters
Introduction
RNA ISH, Why Not?
Issues with RNA ISH
The RNAscope® In Situ Hybridization Platform
RNAscope vs. Traditional RNA ISH
RNAscope vs. IHC - Overview
RNAscope vs. IHC: similar ease of interpretation
RNAscope Methodologies
RNAscope® IVD Automation (Leica Bond III)
Seamless Fit Into Clinical Lab and Pathology Workflows
Diagnostic Applications of RNAscope
RNAscope is more sensitive than IHC for detection of light chain restriction in B Cell lymphomas
PD-L2 Detection for Subtyping Large B Cell Lymphomas
MDM2 in Dx of Lipoma vs. WDLPS
MMR Expression in Colorectal Carcinoma
RNAscope EBV & CMV assays show increased sensitivity vs. traditional ISH and IHC
Additional Infectious Disease Applications
RNAscope for HPV Detection
Comparison of Tissue-Based Tests for HPV Detection in OPSCC
RNA ISH Testing for HPV in Cervical Lesions
RNAscope HPV - Low Risk vs. High Risk Typing in LSIL
p16 IHC in CIN2/3 versus CIN 1
Unmet Clinical Need – Biomarkers for LSIL
RNAscope HPV is Useful in Distinction of CIN1 vs. Reactive Cervix
RNAscope HPV - Sensitivity in CIN1
RNAscope – Very High Sensitivity and Specificity for CIN1 When Used in Combination with H&E Morphology
Other Applications for RNAscope HPV
Conclusion
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