Lilly Life Sciences Studio (L2S2): A Next Generation Drug Discovery Platform
Ryan Bernhardt
Tuesday, April 7, 2020
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Chapters
Introduction
Outline of Today’s Discussion
Lilly Life Sciences Studio Vision
L2S2 Design and Sustainability Goals
Lilly Biotechnology Center Build
L2S2 Lab Space Evolution
L2S2 Laboratory Footprint
Modular and Collaborative Infrastructure
Early L2S2 Platform Visualization
Automated Connection of Modules
Batch Versus Continuous Automation
Independent Module Integration
Module-Specific Scheduler Software
Autonomous Module Workflows
L2S2 Master Scheduler Software Concept
Master Scheduler Implementation
Master Scheduler Interfaces
Master Scheduler Productization
Master Scheduler in Motion
The Interactive L2S2 Experience
L2S2 Cloud-Based Access
Project Timeline Vision (Phased Approach)
L2S2 Platform (Actual Phased Implementation)
L2S2 Platform Scientific Suite Segregation
L2S2 Construction Timeline
Additional L2S2 Facts and Figures
Automation Integrator Acknowledgments
L2S2 Layout (Module Integrators)
February 2020 is Go Live!
Lilly Life Scienece studio
Outline of Today’s Discussion
The Evolution of R&D in the Life Sciences Industry
The History of Automated Synthesis
Automated Synthesis and Purification Lab (2008-2019)
Over a Decade of Automated Synthesis Expertise at Lilly
DESIGN- Hit Expansion Using ASL Reagents (2015)
RESULTS- Hit Expansion using ASL Reagents (2015)
Opportunity to Improve Semi-Automated ASL/APL Processes
The Future of Laboratory Automation (2015)
Idea-to-Data
L2S2 Scientific and Technical Overview
L2S2 Scientific and Technical Overview cont.
Compound Design- ChemoPrint (Retrosynthesis Tool)
Compound Design- Reagent Availability & Cost Analysis
Automated ChemoPrint Validation (January 2018)
L2S2 Reagent and Consumable Input
L2S2 Standardized Labware and Consumables
Automated Consumable Storage Module
Input/Output Module for Sample Management &Test Suites
Input/Output Module for Synthesis, Analytical, & Purification Suite
On Demand Solvent Dispense/Delivery System
Just In Time/Flat Pricing Reagent Ordering
L2S2 Reagent and Consumable Management
Weigh Station Module
Ambient and Cold Material Management Modules
Make – Automated Compound Synthesis
Reaction Preparation Module
Material Transfer Technology Validation (April 2018)
SMOLE Encapsulation Demo Video
Conventional Reaction Execution Module
Indigo Reactors Technical and Safety Features
First Chemistry Reaction Execution & Synthesis on L2S2 (Dec 2018)
First 5 Chemistries Validated in 2019 (~15 more in 2020)
SPE and WorkUp Module
Analytical and Characterization Module
LC/MS Sample Transport to Analytical Module
Data Analysis Software for Analytical & Purification
Preparative Purification Module
L2S2 Fully Automated Analytical Approach Overview
Reformatting, QC, and Characterization Module
L2S2 Compound Storage After Synthesis
Ambient and Cold Material Management Modules
Overall L2S2 Synthesis Process Times
Annual Synthesis Reaction Capacity Per Module Projections*
Complete Chemistry Synthesis Workflow Scheme Example
Perspectives From a Scientist Working in Automation
L2S2 Compound Storage After Synthesis
Compound Storage to Assay Ready Formatting
Biophysical Testing Module
Biological Testing Module
L2S2 Expandable Platform Use Case
L2S2 Collaborators Booth Numbers
Interested in Learning More About Accessing L2S2 Capabilities For Your Scientific Needs?
Finally, Thank You!
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