TCR & BCR Repertoire Analysis and Other Approaches for the Discovery of Drug Targets, Resistance Mechanisms and Biomarkers
Alex Chenchik, PhD
Wednesday, July 10, 2024
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Chapters
Introduction
Gateway to Adaptive Immune System: TCR/BCR Repertoire Analysis & Phenotyping of Immune Cells
Generation of Diverse TCR and BCR Repertoire
Immunophenotyping of Adaptive Immune Responses
DriverMap
TM
Adaptive Immune Receptor (AIR) Profiling Assays
Comprehensive AIR-RNA Repertoire Analysis in Whole Blood and PBMC
How to Quantitate Expression of Immune Receptor Clonotypes?
TRB Clonotype Repertoire Analysis in Blood Samples
Reproducibility in TRB top 100 Clonotype Repertoire Analysis
How to Identify Activated Immune Receptor Clonotypes?
Characterization of Immune Responses after Vaccination
DriverMap Genome-wide Expression Profiling
AIR TCR/BCR Repertoire Analysis in RNA and DNA Samples
Prediction of Vaccine Epitopes with ImmuneWatch DETECT Algorithm
Profiling of Immune Receptors in Metastatic Tumor Samples
AIR repertoire Analysis: Detection of Ag-activated clones
AIR assay: Detection of Neoantigen-Activated Clones
How to Characterize Phenotype of Activated T/B Cells?
Immune Cell Phenotyping > T/B 500 Immune Marker Assay
AIR Immunophenotyping: T/B Cell Fractions vs Single-Cell Analysis
AIR Immunophenotyping in T/B Cell Fractions
AIR & Immunophenotyping for T Cell Sorted Fractions
scAIR TCR/BCR-Mark30 Assay > Phenotyping of Ag-specific T/B cells + Full-length TCR/BCR Chain Info
Summary
Acknowledgments
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