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Overview of AXELIOS sequencing system and research applications in whole genome sequencing

Mitu Chaudhary, Jagdeesh Chandrasekar
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Chapters

  • Introduction
  • Roche sequencing portfolio today: Rich history of technologies
  • Building towards a differentiated clinical sequencing ecosystem
  • Roche Sequencing solution
  • Entering a new space in NGS with Sequencing by Expansion (SBX)
  • SBX Technology
  • SBX Technology: Combination of two powerful innovations
  • AXELIOS High Throughput Sequencing Solution
  • AXELIOS Platform
  • Jagdeesh Chandrasekar: SBX Library Structures and Workflows
  • SBX-Duplex Workflow
  • SBX-D Read Categories
  • SBX-D Variant Calling Performance
  • SBX-D using FFPE Samples
  • SBX-D for Minimal Residual Disease (cfDNA)
  • SBX-Fast
  • SBX Fast Variant Calling Performance
  • Previous SBX-Fast Benchmarking on Coriell Reference Samples
  • SBX-Fast Benchmarking on Coriell Reference Samples
  • AXELIOS Library Prep Workflows
  • Future Application Space for SBX Sequencing
  • SBX at ASHG

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