Large scale single-cell phylogenetic mapping of clonal evolution in aging human tissues
Thursday, December 11, 2025
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Chapters
Introduction
We are genetic mosaics of many genomes
Colonization of entire tissues with age
Phylogenetics to decipher human somatic evolution
Phylogenetics as a temporal microscope
High fidelity single-cell whole genome amplification and large-scale high depth sequencing
In vitro evolutionary experiment
Somatic mutations as endogenous molecular barcodes for short evolutionary time scales
Increasing throughput and decreasing cost of PTA + RNA
Miniaturization and automation of PTA + RNA
Sampling the aging esophagus
Mutation burden of esophageal immune and epithelial cells
Lineage diversification of immune and epithelial cells
Timing tissue resident T cell clonal expansions over lifespan
Divergent trajectories of epithelial clones
Exposure history on global mutational processes and clonal remodeling
Mutation signatures accumulated through lifespan
TP53 mutation landscape in aging esophagus
Prevalent and convergent chromosome 9q cnLOH clones
Chromosome 9q cnLOH clones emerge throughout lifespan and are biased towards early differentiation
Key findings
Acknowledgements
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